Competent synthesis of biaryl analogs via asymmetric Suzuki–Miyaura cross-coupling for the development of anti-inflammatory and analgesic agents

Based on the core structure of diflunisal drug, herein, we report a resembling series biaryl analogs (3a–j) containing halogens, nitro, and methoxy substituents. They were designed synthesized via Suzuki–Miyaura cross-coupling reaction using Pd (OH)2 as catalyst at temperature 65 °C with an intent to obtain improved safer anti-inflammatory analgesic agents. transformation is most significant among reactions since its practical advantages include commercially available low toxic reagents, mild conditions, functional group compatibility. On other hand, few conditions can be used cross-couple aryl boronic acids or esters halides, especially 2-benzyl halides. Because this, novel protocol investigated that facilitates selective conversion halo aromatics, emphasis convert substituted bromobenzene conjugated biphenyls. Finally, obtained tested for in vitro vivo applications. The results showed compound 3b performed better than standard drug IC50 values comparable COX-1 COX-2 inhibition. molecular docking tests effective carried out.